Nanoparticles: Organic Nanoparticles

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Polymeric micelles. Polymeric micelles consist of a core of aggregated hydrophobic polymers surrounded by hydrophilic polymeric chains.

Advantages:

• Their small size and hydrophilic nature allow them to avoid uptake by the reticuloendothelial system, significantly increasing their circulation time.
• Their hydrophilic exterior also allows polymeric micelles to effectively and safely encapsulate very hydrophobic drugs for safe transport through the body.
• Excellent biocompatibility.

Limitations:

• poorly controlled release profiles of encapsulated cargo
• and a high sensitivity to structural change(s)